Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview

doi:10.3390/80400381

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Molecules 2003, 8(4), 381-391; doi:10.3390/80400381

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Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview

Jean Jacques Vanden Eynde^1,2,* and Annie Mayence¹

¹ Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans, LA 70125, USA ² Department of Organic Chemistry, University of Mons-Hainaut, 20 Place du Parc, B-7000 Mons, Belgium

* Author to whom correspondence should be addressed.

Received: 6 March 2003; in revised form: 2 April 2003 / Accepted: 3 April 2003 / Published: 30 April 2003

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Abstract: Domestic microwave ovens as well as laboratory reactors have been successfully employed to prepare dialkyl 1,4-dihydropyridine-3,5-dicarboxylates and to induce the synthesis of the corresponding aromatic derivatives. In that latter particular case, unexpected results have been reported.

Keywords: Aromatization; dihydropyridine; Hantzsch; microwave; oxidation; pyridine

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MDPI and ACS Style

Vanden Eynde, J.J.; Mayence, A. Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview. Molecules 2003, 8, 381-391.

AMA Style

Vanden Eynde JJ, Mayence A. Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview. Molecules. 2003; 8(4):381-391.

Chicago/Turabian Style

Vanden Eynde, Jean J.; Mayence, Annie. 2003. "Synthesis and Aromatization of Hantzsch 1,4-Dihydropyridines under Microwave Irradiation. An Overview." Molecules 8, no. 4: 381-391.

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