Molecules 2002, 7(8), 681-689; doi:10.3390/70800681
Article

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

Li-Xue Zhang 1,* email, An-Jiang Zhang 1 , Xian-Xing Chen 1 , Xin-Xiang Lei 1 , Xiang-Yun Nan 1 , Dong-Yong Chen 1  and Zi-Yi Zhang 2
1 Department of Chemistry, Wenzhou Normal College, Wenzhou 325003, P.R. China 2 Department of Chemistry, Lanzhou University, Lanzhou 730000, P.R. China
* Author to whom correspondence should be addressed.
Published: 31 August 2002
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Abstract: 3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (2). The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectra. The bioassay indicated most of the title compounds possess significant growth promoting effects on mung bean radicles.
Keywords: Furan ring; triazolothiadiazoles; synthesis; spectral characterization; biological activity

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MDPI and ACS Style

Zhang, L.-X.; Zhang, A.-J.; Chen, X.-X.; Lei, X.-X.; Nan, X.-Y.; Chen, D.-Y.; Zhang, Z.-Y. Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles. Molecules 2002, 7, 681-689.

AMA Style

Zhang L-X, Zhang A-J, Chen X-X, Lei X-X, Nan X-Y, Chen D-Y, Zhang Z-Y. Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles. Molecules. 2002; 7(8):681-689.

Chicago/Turabian Style

Zhang, Li-Xue; Zhang, An-Jiang; Chen, Xian-Xing; Lei, Xin-Xiang; Nan, Xiang-Yun; Chen, Dong-Yong; Zhang, Zi-Yi. 2002. "Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles." Molecules 7, no. 8: 681-689.

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