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Molecules 2002, 7(8), 681-689; doi:10.3390/70800681
Article

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles

1,* , 1, 1, 1, 1, 1 and 2
Published: 31 August 2002
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Abstract: 3-(2-Furanyl)-4-amino-5-mercapto-1,2,4-triazole (1) was prepared from 2-furoic acid through a multi-step reaction sequence. Compound 1 reacted with aromatic acids in the presence of phosphorus oxychloride to give 3-(2-furanyl)-6-aryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles (2). The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and mass spectra. The bioassay indicated most of the title compounds possess significant growth promoting effects on mung bean radicles.
Keywords: Furan ring; triazolothiadiazoles; synthesis; spectral characterization; biological activity Furan ring; triazolothiadiazoles; synthesis; spectral characterization; biological activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, L.-X.; Zhang, A.-J.; Chen, X.-X.; Lei, X.-X.; Nan, X.-Y.; Chen, D.-Y.; Zhang, Z.-Y. Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles. Molecules 2002, 7, 681-689.

AMA Style

Zhang L-X, Zhang A-J, Chen X-X, Lei X-X, Nan X-Y, Chen D-Y, Zhang Z-Y. Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles. Molecules. 2002; 7(8):681-689.

Chicago/Turabian Style

Zhang, Li-Xue; Zhang, An-Jiang; Chen, Xian-Xing; Lei, Xin-Xiang; Nan, Xiang-Yun; Chen, Dong-Yong; Zhang, Zi-Yi. 2002. "Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles." Molecules 7, no. 8: 681-689.


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