Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates

doi:10.3390/70800601

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Molecules 2002, 7(8), 601-617; doi:10.3390/70800601

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Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates

Thomas Netscher* and Patrick Bohrer

Research and Development, Roche Vitamins Ltd, CH-4070 Basel, Switzerland

* Author to whom correspondence should be addressed.

Received: 16 May 2002; in revised form: 13 August 2002 / Accepted: 24 August 2002 / Published: 31 August 2002

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Abstract: The trichloromethylsulfonyl-, dichloromethylsulfonyl-, chlorosulfonyl-, and fluorosulfonyl esters of a neopentyl-type alcohol have been prepared via sulfonylation or sulfinylation followed by oxidation. The preparative usefulness and potential of the transformations are discussed.

Keywords: Alkylation reagents; SN2 substitution reactions; steric hindrance; sulfonic esters; sulfur-oxygen bond cleavage.

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MDPI and ACS Style

Netscher, T.; Bohrer, P. Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates. Molecules 2002, 7, 601-617.

AMA Style

Netscher T, Bohrer P. Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates. Molecules. 2002; 7(8):601-617.

Chicago/Turabian Style

Netscher, Thomas; Bohrer, Patrick. 2002. "Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates." Molecules 7, no. 8: 601-617.

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