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Chemoinformatics and Drug Discovery
Molecules 2002, 7(8), 601-617; doi:10.3390/70800601
Article

Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates

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Received: 16 May 2002 / Revised: 13 August 2002 / Accepted: 24 August 2002 / Published: 31 August 2002
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Abstract

The trichloromethylsulfonyl-, dichloromethylsulfonyl-, chlorosulfonyl-, and fluorosulfonyl esters of a neopentyl-type alcohol have been prepared via sulfonylation or sulfinylation followed by oxidation. The preparative usefulness and potential of the transformations are discussed.
Keywords: Alkylation reagents; SN2 substitution reactions; steric hindrance; sulfonic esters; sulfur-oxygen bond cleavage. Alkylation reagents; SN2 substitution reactions; steric hindrance; sulfonic esters; sulfur-oxygen bond cleavage.
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Netscher, T.; Bohrer, P. Towards Highly Activating Leaving Groups: Studies on the Preparation of Some Halogenated Alkyl Sulfonates. Molecules 2002, 7, 601-617.

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