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Molecules 2002, 7(6), 469-474; doi:10.3390/70600469
Article

Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B

 and *
Bayer-AG, Business Group Pharma, Research, 42096 Wuppertal, Germany
* Author to whom correspondence should be addressed.
Received: 2 May 2002 / Revised: 10 June 2002 / Accepted: 14 June 2002 / Published: 30 June 2002
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Abstract

The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the β-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.
Keywords: TAN 1057 A; B; dipeptide antibiotics; combinatorial chemistry TAN 1057 A; B; dipeptide antibiotics; combinatorial chemistry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Aguilar, N.; Krüger, J. Toward a Library Synthesis of the Natural Dipeptide Antibiotic TAN 1057 A,B. Molecules 2002, 7, 469-474.

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