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Molecules 2002, 7(10), 767-776; doi:10.3390/71000767
Article

Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines

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Published: 31 October 2002
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Abstract: A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized using (2S)-1-azido-2-[bis(tert-butoxycarbonyl)-amino]-5-oxopentane as key-intermediate compound.
Keywords: amino acids; amino aldehydes; diamines; tetramines; Wittig reaction amino acids; amino aldehydes; diamines; tetramines; Wittig reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Loukas, V.; Markidis, T.; Kokotos, G. Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines. Molecules 2002, 7, 767-776.

AMA Style

Loukas V, Markidis T, Kokotos G. Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines. Molecules. 2002; 7(10):767-776.

Chicago/Turabian Style

Loukas, Vassilios; Markidis, Theodoros; Kokotos, George. 2002. "Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines." Molecules 7, no. 10: 767-776.


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