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Molecules 2002, 7(10), 767-776; doi:10.3390/71000767
Article

Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines

,  and *
Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece
* Author to whom correspondence should be addressed.
Published: 31 October 2002
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Abstract

A method for the synthesis of long chain diamines and tetramines starting from natural α-amino acids is reported. Diamines and tetramines were prepared through the Wittig olefination reaction of N-protected amino aldehydes obtained from phenylalanine and lysine. A 1,2,17,18-tetramine was synthesized using (2S)-1-azido-2-[bis(tert-butoxycarbonyl)-amino]-5-oxopentane as key-intermediate compound.
Keywords: amino acids; amino aldehydes; diamines; tetramines; Wittig reaction amino acids; amino aldehydes; diamines; tetramines; Wittig reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Loukas, V.; Markidis, T.; Kokotos, G. Amino Acid Based Synthesis of Chiral Long Chain Diamines and Tetramines. Molecules 2002, 7, 767-776.

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