Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives
Abstract
:Introduction
Results and discussion
Code | R1 | R2 | R3 |
BG 138 | -SCH3 | -OCH3 | -H |
BG 981 | -SCH2CH3 | -OCH3 | -H |
BG 980 | -SCH2 CH2CH3 | -OCH3 | -H |
BG 463 | -H | -NH2 |
Substance | K(TB-α-CD; cTB-α-CD~0-10 mmol) [M-1] | Kf(TB-α-CD; cTB-α-CD~20-100 mmol) [M-1] | K(α-CD; cα-CD~0-100 mmol) [M-1] |
---|---|---|---|
BG138 | 341.6±3.2 | 3.1±0.6 | 6.1±1.6 |
BG981 | 571.0±5.6 | 5.8±0.8 | 12.0±1.9 |
BG463 | 556.2±19.4 | 31.0±3.1 | 79.6±5.6 |
BG980 | 276.9±4.5 | 7.7±1.2 | 21.1±4.6 |
Substance | K (α-CD) [M-1] | K (β-CD) [M-1] | K (γ-CD) [M-1] | K (TB-α-CD) [M-1] | K (TB-β-CD) [M-1] | K (TB-γ-CD) [M-1] |
---|---|---|---|---|---|---|
m-F-b | 9.6±7.2 | 7.3±6.1 | 9.8±6.3 | 8.3±6.0 | 5.3±3.6 | 6.5±5.1 |
m-Cl-b | 75.5±4.2 | 10.4±4.2 | 16.1±3.1 | 53.8±4.2 | 9.8±2.3 | 17.5±2.4 |
m-Br-b | 95.7±7.5 | 35.2±21.1 | 21.2±1.9 | 110.7±4.9 | 40.2±4.1 | 23.4±0.6 |
m-I-b | 340.2±30.5 | 115.5±15.2 | 34.0±2.6 | 260.5±12.6 | 88.6±6.3 | 31.6±1.9 |
p-F-b | 52.6±36.2 | 30±18.2 | 27.9±11.1 | 19.9±3.2 | 12.2±1.7 | 22.7±3.1 |
p-Cl-b | 114.5±8.3 | 72.5±20.2 | 25.7±5.6 | 114.6±0.6 | 65.2±3.0 | 24.3±4.8 |
p-Br-b | 282.0±12.1 | 130.2±26.8 | 28.6±4.5 | 228.8±0.6 | 126.2±3.1 | 30.5±3.2 |
p-I-b | 580.8±20.5 | 322.6±32.7 | 41.2±2.5 | 570.8±2.7 | 323.6±6.2 | 44.1±1.7 |
Conclusions
Acknowledgments
Experimental
Procedure
Plotting form | K | μc−μf |
---|---|---|
Materials
tert-Butyl-cyclodextrins (TB-CDs)
Instrumentation
CE measurement of association constant of benzoic acid derivatives
CE measurement of association constant of 9-alkylthioacridine derivatives
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Pumera, M.; Matalová, R.; Jelínek, I.; Jindřich, J.; Jůza, J. Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives. Molecules 2001, 6, 221-229. https://doi.org/10.3390/60300221
Pumera M, Matalová R, Jelínek I, Jindřich J, Jůza J. Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives. Molecules. 2001; 6(3):221-229. https://doi.org/10.3390/60300221
Chicago/Turabian StylePumera, Martin, Radka Matalová, Ivan Jelínek, Jindřich Jindřich, and Josef Jůza. 2001. "Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives" Molecules 6, no. 3: 221-229. https://doi.org/10.3390/60300221