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Molecules 2001, 6(1), 13-20; doi:10.3390/60100013
Article

Tricarbonyl(h6-Arene)Chromium(0) Complexes as Chiral Auxiliaries: Asymmetric Synthesis of b-Lactones

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Received: 24 July 2000 / Revised: 18 December 2000 / Accepted: 18 December 2000 / Published: 16 January 2001
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Abstract

The optically pure tricarbonyl(h6-2-substituted benzaldehydes)chromium are used as chiral auxiliaries in the condensation with a series of doubly lithiated carboxylic acids. The intramolecular ring closure of the obtained Cr(CO)3 complexed b-hydroxyacids affords the optically pure b-lactones in satisfactory yield.
Keywords: b-lactones; stereoselective synthesis; 2-oxetanones; chromiumtricarbonyl benzaldehydes b-lactones; stereoselective synthesis; 2-oxetanones; chromiumtricarbonyl benzaldehydes
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Buttero, P.D.; Montrasio, D. Tricarbonyl(h6-Arene)Chromium(0) Complexes as Chiral Auxiliaries: Asymmetric Synthesis of b-Lactones. Molecules 2001, 6, 13-20.

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