Novel Coumarin Derivatives with Expected Biological Activity

doi:10.3390/50200099

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Molecules 2000, 5(2), 99-113; doi:10.3390/50200099

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Novel Coumarin Derivatives with Expected Biological Activity

Z. M. Nofal * , M. I. El-Zahar and S. S. Abd El-Karim

Therapeutical Chemistry Department, National Research Centre, Dokki, Cairo, Egypt

* Author to whom correspondence should be addressed.

Received: 13 August 1999 / Accepted: 20 October 1999 / Published: 16 February 2000

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Abstract: A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro on Ehrlich ascites carcinoma in the preliminary testing.

Keywords: Substituted coumarins; nitro reduction; benzylidinyl amino coumarins

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MDPI and ACS Style

Nofal, Z.M.; El-Zahar, M.I.; Abd El-Karim, S.S. Novel Coumarin Derivatives with Expected Biological Activity. Molecules 2000, 5, 99-113.

AMA Style

Nofal Z.M., El-Zahar M.I., Abd El-Karim S.S. Novel Coumarin Derivatives with Expected Biological Activity. Molecules. 2000; 5(2):99-113.

Chicago/Turabian Style

Nofal, Z. M.; El-Zahar, M. I.; Abd El-Karim, S. S. 2000. "Novel Coumarin Derivatives with Expected Biological Activity." Molecules 5, no. 2: 99-113.

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