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Molecules 2000, 5(2), 153-161; doi:10.3390/50200153
Article

Synthesis of 4-O-Methylcedrusin. Selective Protection of Catechols with Diphenyl Carbonate

, * ,  and
Department of Chemistry, Laboratory of Natural Product Synthesis for Chemotherapy, University of Antwerp (RUCA), Groenenborgerlaan 171, 2020 Antwerpen, Belgium
* Author to whom correspondence should be addressed.
Received: 1 November 1999 / Accepted: 19 January 2000 / Published: 18 February 2000
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Abstract

4-O-Methylcedrusin, a minor component in ‘sangre de drago’, has been synthesized using a strategy of successive protection and deprotection reactions under very mild conditions. The key step of this synthesis is a selective protection of a catechol group as a cyclic carbonate in the presence of an isolated phenol group.
Keywords: Carbonates; lignans; phenolics; protecting groups; natural products Carbonates; lignans; phenolics; protecting groups; natural products
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Van Dyck, S.M.O.; Lemière, G.L.F.; Jonckers, T.H.M.; Dommisse, R. Synthesis of 4-O-Methylcedrusin. Selective Protection of Catechols with Diphenyl Carbonate. Molecules 2000, 5, 153-161.

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