Unexpected Thorpe Reaction of an α-Alkoxynitrile
Abstractα-Alkoxynitrile 1 in the presence of tris(methylthio)methyllithium 2 at –78ºC gave the dimer 5 instead of the expected C1-elongated product 3. The formation of compound 5 is explained in terms of anion formation and self-condensation, a variant of the Thorpe reaction. Scrutinizing the 1H NMR spectra revealed that the enamine tautomer 5b is predominant over the imine 5a in the solvents investigated.
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Kovács, L. Unexpected Thorpe Reaction of an α-Alkoxynitrile. Molecules 2000, 5, 127-131.
Kovács L. Unexpected Thorpe Reaction of an α-Alkoxynitrile. Molecules. 2000; 5(2):127-131.Chicago/Turabian Style
Kovács, Lajos. 2000. "Unexpected Thorpe Reaction of an α-Alkoxynitrile." Molecules 5, no. 2: 127-131.