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Molecules 2000, 5(1), 82-88; doi:10.3390/50100082

A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone

Cancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK
Department of Biological Sciences, Salford University, Salford, M5 4WT, UK
Author to whom correspondence should be addressed.
Received: 2 November 1999 / Accepted: 12 January 2000 / Published: 18 January 2000
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A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7).
Keywords: Irisquinone; antitumour; Chinese medicine Irisquinone; antitumour; Chinese medicine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hadfield, J.A.; McGown, A.T.; Butler, J. A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone. Molecules 2000, 5, 82-88.

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