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Molecules 2000, 5(1), 82-88; doi:10.3390/50100082
Article

A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone

1,* , 1 and 2
1 Cancer Research Campaign Section of Drug Development and Imaging, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester, M20 4BX, UK 2 Department of Biological Sciences, Salford University, Salford, M5 4WT, UK
* Author to whom correspondence should be addressed.
Received: 2 November 1999 / Accepted: 12 January 2000 / Published: 18 January 2000
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Abstract

A short, high-yielding synthesis of the antitumour agent irisquinone (1) is described. The key steps are the palladium catalysed coupling reaction of dec-9-yn-1-ol with iodide (2) to form alkyne (3) and the Fremy’s salt oxidation of phenol (7).
Keywords: Irisquinone; antitumour; Chinese medicine Irisquinone; antitumour; Chinese medicine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hadfield, J.A.; McGown, A.T.; Butler, J. A High-Yielding Synthesis of the Naturally Occurring Antitumour Agent Irisquinone. Molecules 2000, 5, 82-88.

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