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Recent Developments in the Area of Asymmetric Transfer Hydrogenation
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
SmithKline Beecham Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, Kent, TN11 9AN, UK
* Author to whom correspondence should be addressed.
Received: 14 September 2000; Accepted: 15 November 2000 / Published: 21 January 2001
Abstract: The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
Keywords: asymmetric; transfer; hydrogenation; catalysis; ruthenium
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Wills, M.; Palmer, M.; Smith, A.; Kenny, J.; Walsgrove, T. Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Molecules 2000, 5, 4-18.
Wills M, Palmer M, Smith A, Kenny J, Walsgrove T. Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Molecules. 2000; 5(1):4-18.
Wills, Martin; Palmer, Matthew; Smith, Athene; Kenny, Jennifer; Walsgrove, Tim. 2000. "Recent Developments in the Area of Asymmetric Transfer Hydrogenation." Molecules 5, no. 1: 4-18.