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Molecules 2000, 5(1), 4-18; doi:10.3390/50100004

Recent Developments in the Area of Asymmetric Transfer Hydrogenation

1
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK
2
SmithKline Beecham Pharmaceuticals, Old Powder Mills, Nr Leigh, Tonbridge, Kent, TN11 9AN, UK
*
Author to whom correspondence should be addressed.
Received: 14 September 2000 / Accepted: 15 November 2000 / Published: 21 January 2001
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Abstract

The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
Keywords: asymmetric; transfer; hydrogenation; catalysis; ruthenium asymmetric; transfer; hydrogenation; catalysis; ruthenium
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wills, M.; Palmer, M.; Smith, A.; Kenny, J.; Walsgrove, T. Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Molecules 2000, 5, 4-18.

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