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Molecules 2000, 5(1), 4-18; doi:10.3390/50100004
Review

Recent Developments in the Area of Asymmetric Transfer Hydrogenation

1,* , 1, 1, 1 and 2
Received: 14 September 2000; Accepted: 15 November 2000 / Published: 21 January 2001
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Abstract: The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.
Keywords: asymmetric; transfer; hydrogenation; catalysis; ruthenium asymmetric; transfer; hydrogenation; catalysis; ruthenium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wills, M.; Palmer, M.; Smith, A.; Kenny, J.; Walsgrove, T. Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Molecules 2000, 5, 4-18.

AMA Style

Wills M, Palmer M, Smith A, Kenny J, Walsgrove T. Recent Developments in the Area of Asymmetric Transfer Hydrogenation. Molecules. 2000; 5(1):4-18.

Chicago/Turabian Style

Wills, Martin; Palmer, Matthew; Smith, Athene; Kenny, Jennifer; Walsgrove, Tim. 2000. "Recent Developments in the Area of Asymmetric Transfer Hydrogenation." Molecules 5, no. 1: 4-18.



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