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Molecules 2000, 5(1), 19-32; doi:10.3390/50100019
Article

General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

1, 1,*  and 2
1 Department of Organic Chemistry, Medical University of Sofia, Dunav 2, BG-1000 Sofia, Bulgaria 2 Pharmaceutical Institute, Christian-Albrechts University of Kiel, Gutenbergstr. 76, D-24118 Kiel, Germany
* Author to whom correspondence should be addressed.
Received: 7 December 1999 / Accepted: 31 December 1999 / Published: 21 January 2000
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Abstract

Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran derivatives 3a-3af.
Keywords: pyrano[4; 3-b]pyran; pyrano[3; 2-c]pyridine; arylmethylene malononitrile; arylmethylene cyanoacetate; Michael addition pyrano[4; 3-b]pyran; pyrano[3; 2-c]pyridine; arylmethylene malononitrile; arylmethylene cyanoacetate; Michael addition
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stoyanov, E.V.; Ivanov, I.C.; Heber, D. General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones. Molecules 2000, 5, 19-32.

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