Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone

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Molecules 1999, 4(7), 232-237; doi:10.3390/40700232

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Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone

Sayeed Mukhtar¹, Mujeebur V.P. Rahman¹, Wajid Husain Ansari^1,* , Guy Lemière², Alex De Groot² and Roger Dommisse²

¹ Department of Chemistry, Aligarh Muslim University, Aligarh-202002, India ² Department of Chemistry (Natural Products), University of Antwerp (RUCA), Groenenborgerlaan 171, B-2020 Antwerp, Belgium

* Author to whom correspondence should be addressed.

Received: 3 March 1999 / Accepted: 10 June 1999 / Published: 19 July 1999

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Abstract: The synthesis of 2-[2-carboxymethylthio-2-(4-chlorophenyl) ethyl]-2-(4-chlorophenyl) - 4-thiazolidinone (1) from p, p'- dichlorochalcone using thioglycollic acid in the presence of ammonium carbonate is described. Structural assignment and stereochemistry are discussed.

Keywords: Organic synthesis; chalcone; thiazolidinone; 1H-NMR; 13C-NMR

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MDPI and ACS Style

Mukhtar, S.; Rahman, M.V.; Ansari, W.H.; Lemière, G.; De Groot, A.; Dommisse, R. Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone. Molecules 1999, 4, 232-237.

AMA Style

Mukhtar S, Rahman MV, Ansari WH, Lemière G, De Groot A, Dommisse R. Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone. Molecules. 1999; 4(7):232-237.

Chicago/Turabian Style

Mukhtar, Sayeed; Rahman, Mujeebur V.; Ansari, Wajid H.; Lemière, Guy; De Groot, Alex; Dommisse, Roger. 1999. "Bifunctional Derivative of p,p'-Dichlorochalcone. Part II. Synthesis of a Novel Compound 2-[2-Carboxymethylthio-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)-4-thiazolidinone." Molecules 4, no. 7: 232-237.

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