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Molecules 1998, 3(3), 64-70; doi:10.3390/30300064
Article

An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds

*  and
Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK
* Author to whom correspondence should be addressed.
Received: 10 January 1998 / Accepted: 16 February 1998 / Published: 20 February 1998
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Abstract

A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using an intramolecular Diels-Alder reaction have been successful.
Keywords: Taxol; cation-mediated cascade cyclisation; asymmetric Diels-Alder reaction Taxol; cation-mediated cascade cyclisation; asymmetric Diels-Alder reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Craig, D.; Marin, M.L. An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds. Molecules 1998, 3, 64-70.

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