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Molecules 1998, 3(3), 64-70; doi:10.3390/30300064
Article

An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds

*  and
Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK
* Author to whom correspondence should be addressed.
Received: 10 January 1998 / Accepted: 16 February 1998 / Published: 20 February 1998
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Abstract

A synthetic route developed for the preparation of the A-ring of Taxol family of molecules is reported. By means of an intramolecular Diels-Alder reaction an asymmetric approach to this ring has been accomplished. Also, initial studies to prepare the A ring using an intramolecular Diels-Alder reaction have been successful.
Keywords: Taxol; cation-mediated cascade cyclisation; asymmetric Diels-Alder reaction Taxol; cation-mediated cascade cyclisation; asymmetric Diels-Alder reaction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Craig, D.; Marin, M.L. An Asymmetric Synthetic Approach to the A-ring of the Taxol Family of Anti-Cancer Compounds. Molecules 1998, 3, 64-70.

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