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Molecules 2018, 23(9), 2260; https://doi.org/10.3390/molecules23092260

Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase

1
Department of Life Science and Institute of Biotechnology, National Dong-Hwa University, Hualien 97401, Taiwan
2
Neural Regeneration Laboratory, Neurological Institute, Taipei Veterans General Hospital, Taipei 11217, Taiwan
3
Department of Biotechnology and Animal Science, National Ilan University, Ilan 26047, Taiwan
4
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
5
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 94450, Taiwan
6
Department of Chemistry, National Dong Hwa University, Hualien 97401, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 August 2018 / Revised: 31 August 2018 / Accepted: 3 September 2018 / Published: 5 September 2018
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [1630 KB, uploaded 5 September 2018]   |  

Abstract

The inhibition of α-glucosidase and α-amylase is a clinical strategy for the treatment of type II diabetes, and herbal medicines have been reported to credibly alleviate hyperglycemia. Our previous study has reported some constituents from plant or herbal sources targeted to α-glucosidase and α-amylase via molecular docking and enzymatic measurement, but the hypoglycemic potencies in cell system and mice have not been validated yet. This study was aimed to elucidate the hypoglycemic efficacy of docking selected compounds in cell assay and oral glucose and starch tolerance tests of mice. All test compounds showed the inhibition of α-glucosidase activity in Caco-2 cells. The decrease of blood sugar levels of test compounds in 30 min and 60 min of mice after OGTT and OSTT, respectively and the decreased glucose levels of test compounds were significantly varied in acarbose. Taken altogether, in vitro and in vivo experiments suggest that selected natural compounds (curcumin, antroquinonol, HCD, docosanol, tetracosanol, rutin, and actinodaphnine) via molecular docking were confirmed as potential candidates of α-glucosidase and α-amylase inhibitors for treating diabetes. View Full-Text
Keywords: natural compound; α-glucosidase; α-amylase natural compound; α-glucosidase; α-amylase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Riyaphan, J.; Jhong, C.-H.; Lin, S.-R.; Chang, C.-H.; Tsai, M.-J.; Lee, D.-N.; Sung, P.-J.; Leong, M.K.; Weng, C.-F. Hypoglycemic Efficacy of Docking Selected Natural Compounds against α-Glucosidase and α-Amylase. Molecules 2018, 23, 2260.

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