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Molecules 2018, 23(9), 2221; https://doi.org/10.3390/molecules23092221

Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae

1
Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
2
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany
3
Biology Unit, Central Laboratory for Pharmaceutical and Drug Industries Research Division, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt
4
Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt
5
Phytochemistry Lab., National Organization for Drug Control and Research, Giza 12622, Egypt
6
Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan
7
Department of Pharmacognosy, Helwan University, Cairo 12622, Egypt
8
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
*
Author to whom correspondence should be addressed.
Received: 28 July 2018 / Revised: 14 August 2018 / Accepted: 15 August 2018 / Published: 1 September 2018
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Euphorbia species are rich in diterpenes. A solvent extraction of Euphorbia sanctae-catharinae, a species indigenous to the Southern Sinai of Egypt, afforded several premyrsinane diterpenoids (14) as well as previously reported metabolites (513) that included three flavonoids. Isolated compounds were chemically characterized by spectroscopic analysis. Identified compounds were bioassayed for anti-proliferative activity in vitro against colon (Caco-2) and lung (A549) tumor cell lines. Compound 9 exhibited robust anti-proliferative activity against A549 cells (IC50 = 3.3 µM). Absolute configurations for 8 versus 9 were determined by experimental and TDDFT-calculated electronic circular dichorism (ECD) spectra. View Full-Text
Keywords: Euphorbia sanctae-catharinae; Euphorbiaceae; diterpenes; flavonoids; TDDTF-ECD; tumor anti-proliferative activity Euphorbia sanctae-catharinae; Euphorbiaceae; diterpenes; flavonoids; TDDTF-ECD; tumor anti-proliferative activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hegazy, M.-E.F.; Hamed, A.R.; Ibrahim, M.A.A.; Talat, Z.; Reda, E.H.; Abdel-Azim, N.S.; Hammouda, F.M.; Nakamura, S.; Matsuda, H.; Haggag, E.G.; Paré, P.W.; Efferth, T. Euphosantianane A–D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae. Molecules 2018, 23, 2221.

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