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Molecules 2018, 23(8), 2013; https://doi.org/10.3390/molecules23082013

Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations

1
Departament of Chemistry, Universidad de los Andes, Carrera 1 No. 18A-12, 111711 Bogotá, Colombia
2
Programa de Bacteriología y Laboratorio Clínico, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia
3
Programa de Maestría en Investigación en Enfermedades Infecciosas, Facultad de Ciencias de la Salud, Universidad de Santander, 680002 Bucaramanga, Colombia
4
Facultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué, Carrera 22 Calle 67, 730001 Ibagué, Colombia
5
Grupo de Química Inorgánica y Materiales Moleculares, Universidad Autonoma de Chile, El Llano Subercaseaux, 2801 Santiago, Chile
*
Author to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 31 July 2018 / Accepted: 4 August 2018 / Published: 13 August 2018
(This article belongs to the Section Inorganic Chemistry)
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Abstract

In this work, six complexes (27) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 37 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great interest, as they showed minimum inhibitory concentration 50 (MIC50) values between 7.8 and 15.6 μg mL−1. Complexes 5 and 6 showed little effect on Vero cells, indicating that they are not cytotoxic. These results can provide an important platform for the design of new compounds with antibacterial and antifungal activities. View Full-Text
Keywords: triazole ligands; cobalt(II) and chromium(III) complexes; antibacterial activity; antifungal activity triazole ligands; cobalt(II) and chromium(III) complexes; antibacterial activity; antifungal activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Murcia, R.A.; Leal, S.M.; Roa, M.V.; Nagles, E.; Muñoz-Castro, A.; Hurtado, J.J. Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations. Molecules 2018, 23, 2013.

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