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Molecules 2018, 23(8), 1922; https://doi.org/10.3390/molecules23081922

Transition-Metal-Free C(sp3)–H Oxidation of Diarylmethanes

1
Department of Pharmacy, School of Medicine, Zhejiang University City College, No. 48, Huzhou Road, Hangzhou 310015, China
2
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
*
Author to whom correspondence should be addressed.
Received: 10 July 2018 / Revised: 25 July 2018 / Accepted: 27 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue Recent Development on Metal-Free Catalysis)
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Abstract

An efficient direct C(sp3)–H oxidation of diarylmethanes has been demonstrated by this study. This method employs environment-friendly O2 as an oxidant and is promoted by commercially available MN(SiMe3)2 [M = K, Na or Li], which provides a facile method for the synthesis of various diaryl ketones in excellent yields. This protocol is metal-free, mild and compatible with a number of functional groups on substrates. View Full-Text
Keywords: metal-free; diarylmethane; oxidation; ketone metal-free; diarylmethane; oxidation; ketone
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Yang, F.; Zhou, B.; Chen, P.; Zou, D.; Luo, Q.; Ren, W.; Li, L.; Fan, L.; Li, J. Transition-Metal-Free C(sp3)–H Oxidation of Diarylmethanes. Molecules 2018, 23, 1922.

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