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Molecules 2018, 23(7), 1821; https://doi.org/10.3390/molecules23071821

A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability

1,2,†
,
1,†
,
2
,
1
,
3
,
2,4
,
5
and
2,4,*
1
College of Biotechnology, Southwest University, Beibei, Chongqing 400715, China
2
State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400715, China
3
College of Pharmaceutical Sciences, Southwest University, Beibei, Chongqing 400715, China
4
Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Beibei, Chongqing 400715, China
5
Department of Chemistry, College of Science and Arts and Promising Centre for Sensors and Electronics Devices, Najran University, P.O. Box 1988, Najran 11001, Saudi Arabia
These authors have equal contributions to this work.
*
Author to whom correspondence should be addressed.
Received: 17 June 2018 / Revised: 5 July 2018 / Accepted: 11 July 2018 / Published: 23 July 2018
(This article belongs to the Special Issue Nanocomposites of Polymers and Inorganic Particles)
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Abstract

Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability against Escherichia coli and Staphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications. View Full-Text
Keywords: silk sericin; agar; silver nanoparticles; antimicrobial activity silk sericin; agar; silver nanoparticles; antimicrobial activity
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Wang, Y.; Cai, R.; Tao, G.; Wang, P.; Zuo, H.; Zhao, P.; Umar, A.; He, H. A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability. Molecules 2018, 23, 1821.

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