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Molecules 2018, 23(7), 1816; https://doi.org/10.3390/molecules23071816

New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana

Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, 2st Cuihu North Road, Kunming 650091, China
These authors contributed equally to this work.
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Received: 29 June 2018 / Revised: 17 July 2018 / Accepted: 18 July 2018 / Published: 21 July 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

In this study, the co-culture of Nigrospora oryzae and Beauveria bassiana, the endophytes in the seeds of Dendrobium officinale, were examined for metabolite diversity. Five new azaphilones were isolated, and their structures were determined by spectral analysis. In terms of azaphilones, compound 2 had an unprecedented skeleton, with a bicyclic oxygen bridge. The antifungal selectivities of the metabolite produced by N. oryzae against its co-culture fungus, B. bassiana, and common pathogens exhibited competitive interaction in this mix-culture. Compounds 1 and 2 showed obvious nitric oxide (NO) inhibitory activity with ratios of 37%, and 39%, respectively, at a concentration of 50 μM. View Full-Text
Keywords: Nigrospora oryzae; Beauveria bassiana; co-culture; azaphilone; antifungal selectivity; NO inhibitory activity Nigrospora oryzae; Beauveria bassiana; co-culture; azaphilone; antifungal selectivity; NO inhibitory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, Z.-X.; Yang, X.-Q.; Zhou, Q.-Y.; Wang, B.-Y.; Hu, M.; Yang, Y.-B.; Zhou, H.; Ding, Z.-T. New Azaphilones from Nigrospora oryzae Co-Cultured with Beauveria bassiana. Molecules 2018, 23, 1816.

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