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Molecules 2018, 23(7), 1719; https://doi.org/10.3390/molecules23071719

Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations

1
Department of Pharmaceutical Sciences, School of Pharmacy, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA
2
ICPH Fairfax Bernard J. Dunn School of Pharmacy, Shenandoah University, Fairfax, VA 22031, USA
3
Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY 14618, USA
4
Department of Pharmaceutical Sciences, USF College of Pharmacy, Tampa, FL 33612, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Wipf
Received: 7 June 2018 / Revised: 12 July 2018 / Accepted: 13 July 2018 / Published: 14 July 2018
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Abstract

The physicochemical and biological properties of active pharmaceutical ingredients (APIs) are greatly affected by their salt forms. The choice of a particular salt formulation is based on numerous factors such as API chemistry, intended dosage form, pharmacokinetics, and pharmacodynamics. The appropriate salt can improve the overall therapeutic and pharmaceutical effects of an API. However, the incorrect salt form can have the opposite effect, and can be quite detrimental for overall drug development. This review summarizes several criteria for choosing the appropriate salt forms, along with the effects of salt forms on the pharmaceutical properties of APIs. In addition to a comprehensive review of the selection criteria, this review also gives a brief historic perspective of the salt selection processes. View Full-Text
Keywords: chemistry; salt; water solubility; routes of administration; physicochemical; stability; degradation chemistry; salt; water solubility; routes of administration; physicochemical; stability; degradation
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Gupta, D.; Bhatia, D.; Dave, V.; Sutariya, V.; Varghese Gupta, S. Salts of Therapeutic Agents: Chemical, Physicochemical, and Biological Considerations. Molecules 2018, 23, 1719.

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