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Molecules 2018, 23(7), 1694; https://doi.org/10.3390/molecules23071694

Controlled Release of DEET Loaded on Fibrous Mats from Electrospun PMDA/Cyclodextrin Polymer

1
Department of Chemistry and NIS Centre, University of Turin, Via P. Giuria 7, 10125 Torino, Italy
2
ICxT Centre, University of Turin, Lungo Dora Siena 100, 10153 Torino, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Bernard Martel
Received: 11 June 2018 / Revised: 29 June 2018 / Accepted: 9 July 2018 / Published: 11 July 2018
(This article belongs to the Special Issue Cyclodextrin Chemistry 2018)
Full-Text   |   PDF [1166 KB, uploaded 12 July 2018]   |  

Abstract

Electrospun beta-cyclodextrin (βCD)-based polymers can combine a high surface-to-volume ratio and a high loading/controlled-release-system potential. In this work, pyromellitic dianhydride (PMDA)/βCD-based nanosponge microfibers were used to study the capability to host a common insect repellent (N,N-diethyl-3-toluamide (DEET)) and to monitor its release over time. Fibrous samples characterized by an average fibrous diameter of 2.8 ± 0.8 µm were obtained and subsequently loaded with DEET, starting from a 10 g/L diethyl ether (DEET) solution. The loading capacity of the system was assessed via HPLC/UV–Vis analysis and resulted in 130 mg/g. The releasing behavior was followed by leaving fibrous DEET-loaded nanosponge samples in air at room temperature for a period of between 24 h and 2 weeks. The releasing rate and the amount were calculated by thermogravimetric analysis (TGA), and the release of the repellent was found to last for over 2 weeks. Eventually, both the chemical composition and sample morphology were proven to play a key role for the high sample loading capacity, determining the microfibers’ capability to be applied as an effective controlled-release system. View Full-Text
Keywords: N,N-diethyl-3-toluamide (DEET); insect repellent; beta-cyclodextrin-based polymer; fibrous nanosponge; controlled-release system N,N-diethyl-3-toluamide (DEET); insect repellent; beta-cyclodextrin-based polymer; fibrous nanosponge; controlled-release system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cecone, C.; Caldera, F.; Trotta, F.; Bracco, P.; Zanetti, M. Controlled Release of DEET Loaded on Fibrous Mats from Electrospun PMDA/Cyclodextrin Polymer. Molecules 2018, 23, 1694.

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