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Molecules 2018, 23(7), 1654; https://doi.org/10.3390/molecules23071654

Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells

1,†
,
1,2,†,* , 1
,
1
and
1,2,*
1
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China
2
Department of Traditional Chinese Medicine, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 14 April 2018 / Revised: 26 June 2018 / Accepted: 26 June 2018 / Published: 6 July 2018
(This article belongs to the Section Chemical Biology)
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Abstract

Dibutyltin dilaurate (DBTD) has multiple applications in daily life. However, DBTD is easily deposited in the liver and affects liver functions. This study was designed to explore the effects of DBTD on triglyceride metabolism in human normal hepatocyte HL7702 cells. Our results showed that the intracellular fat contents were dose-dependently decreased by DBTD. The expression of lipolysis genes and proteins were elevated while the lipogenesis genes and proteins were diminished by DBTD. The phosphorylation levels of ribosomal S6 kinase 1 were reduced by both rapamycin and DBTD, indicating that the mTOR pathway was suppressed possibly. The decreased sterol regulatory element-binding protein 1C (SREBP1C) transcription levels, as well as the increased peroxisome proliferator-activated receptor alpha (PPARα) transcription levels, caused by rapamycin and DBTD corresponded to the inactive mTOR pathway. In conclusion, it was possible that DBTD reduced the intracellular triglyceride through depressing the mTOR pathway and affecting its downstream transcription factors. View Full-Text
Keywords: dibutyltin dilaurate (DBTD); triglycerides metabolism; mTOR pathway; SREBP1C; PPARα dibutyltin dilaurate (DBTD); triglycerides metabolism; mTOR pathway; SREBP1C; PPARα
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Qiao, X.; Li, Y.; Mai, J.; Ji, X.; Li, Q. Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells. Molecules 2018, 23, 1654.

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