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Molecules 2018, 23(6), 1392; https://doi.org/10.3390/molecules23061392

Protective Effects on 60Co-γ Radiation Damage of Pine Cone Polyphenols from Pinus koraiensis-Loaded Chitosan Microspheres In Vivo

1
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Nangang District, Harbin 150090, China
2
School of Life Sciences, Zhengzhou University, Zhengzhou 450000, Henan, China
3
Department of Food Science, Cornell University, Ithaca, NY 14853-7201, USA
*
Author to whom correspondence should be addressed.
Received: 8 May 2018 / Revised: 2 June 2018 / Accepted: 4 June 2018 / Published: 8 June 2018
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Abstract

A novel chitosan microsphere for encapsulating pine cone polyphenols (PP) from P. koraiensis was successfully prepared using an emulsion crosslinking technique. The characteristics of pine polyphenol-loaded microspheres (PPM) were determined using scanning electron microscopy (SEM) and a laser particle size detector. It was found that PPMs were spherical in shape with uniform particle size distribution patterns. The drug content and encapsulation rate of the microspheres were 7.47% and 73.6%, respectively, at a Ch/GA mass ratio of 0.7. The animal experiments showed that PPM had a stronger radiation protective effect than PP. PPM significantly increased the immune organ indices, the quantity of marrow DNA, the superoxide dismutase (SOD) activity, the splenocyte proliferation index, and the phagocytosis activity of monocytes. PPM also decreased the numbers of micronuclei in bone marrow cells and malondialdehyde (MDA) levels in plasma in mice exposed to 60Co γ-irradiation. In addition, gender differences in biological responses to exposure to radiation were observed. View Full-Text
Keywords: chitosan microspheres; radioprotection; pine cones; polyphenols; Pinus koraiensis chitosan microspheres; radioprotection; pine cones; polyphenols; Pinus koraiensis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Shao, S.; Yi, J.; Regenstein, J.M.; Cheng, C.; Zhang, H.; Zhao, H.; Wang, Z. Protective Effects on 60Co-γ Radiation Damage of Pine Cone Polyphenols from Pinus koraiensis-Loaded Chitosan Microspheres In Vivo. Molecules 2018, 23, 1392.

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