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Molecules 2018, 23(6), 1281; https://doi.org/10.3390/molecules23061281

Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates

1
Department of Coatings and Polymeric Materials, North Dakota State University, Fargo, ND 58105, USA
2
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin 14195, Germany
3
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC H3A 0G4, Canada
*
Author to whom correspondence should be addressed.
Received: 28 March 2018 / Revised: 14 May 2018 / Accepted: 17 May 2018 / Published: 26 May 2018
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Abstract

Hyperbranched polyglycerol (hPG) has been used as a multivalent scaffold to develop a series of nanocarriers capable of high-affinity encapsulation of copper (Cu). A rationally selected set of Cu-complexing motifs has been conjugated to hPG hydroxyl groups to render the constructs potentially usable as exogenous sources of Cu for addressing different pathological conditions associated with Cu-deficiency. We have utilized a newly discovered route to attach Cu-binding domains exclusively within a hPG core by selective differentiation between the primary and secondary hydroxyl groups of the polyol. These hPG-derivatives were found to form a stable complex with Cu ions depending on the type of immobilized ligands and corresponding degree of functionalization. In addition, these Cu-bearing nano-complexes demonstrated moderately cationic surface charge resulting in adjustable protein-binding characteristics and low cellular toxicity profile. We envision that these Cu-loaded hPG nanocarriers can be used as a stable platform to transport the metal ion across the systemic circulation to supply bioavailable quantity of Cu in disease-afflicted tissues. View Full-Text
Keywords: hyperbranched polyglycerol; nanocarrier; ion transport; Cu-deficiency disorders hyperbranched polyglycerol; nanocarrier; ion transport; Cu-deficiency disorders
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Quadir, M.; Fehse, S.; Multhaup, G.; Haag, R. Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates. Molecules 2018, 23, 1281.

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