Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates
AbstractHyperbranched polyglycerol (hPG) has been used as a multivalent scaffold to develop a series of nanocarriers capable of high-affinity encapsulation of copper (Cu). A rationally selected set of Cu-complexing motifs has been conjugated to hPG hydroxyl groups to render the constructs potentially usable as exogenous sources of Cu for addressing different pathological conditions associated with Cu-deficiency. We have utilized a newly discovered route to attach Cu-binding domains exclusively within a hPG core by selective differentiation between the primary and secondary hydroxyl groups of the polyol. These hPG-derivatives were found to form a stable complex with Cu ions depending on the type of immobilized ligands and corresponding degree of functionalization. In addition, these Cu-bearing nano-complexes demonstrated moderately cationic surface charge resulting in adjustable protein-binding characteristics and low cellular toxicity profile. We envision that these Cu-loaded hPG nanocarriers can be used as a stable platform to transport the metal ion across the systemic circulation to supply bioavailable quantity of Cu in disease-afflicted tissues. View Full-Text
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Quadir, M.; Fehse, S.; Multhaup, G.; Haag, R. Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates. Molecules 2018, 23, 1281.
Quadir M, Fehse S, Multhaup G, Haag R. Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates. Molecules. 2018; 23(6):1281.Chicago/Turabian Style
Quadir, Mohiuddin; Fehse, Susanne; Multhaup, Gerhard; Haag, Rainer. 2018. "Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates." Molecules 23, no. 6: 1281.
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