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Molecules 2018, 23(6), 1277; https://doi.org/10.3390/molecules23061277

N-oxide alkaloids from Crinum amabile (Amaryllidaceae)

1
Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain
2
Department of Chemistry, Federal University of Espírito Santo, Av. Fernando Ferrari 514, 29075-915 Vitoria ES, Brazil
3
Medicinal Parasitology and Infection Biology, Swiss Tropical Institure, Socinstrasse 57, 4051 Basel, Switzerland
4
University of Basel, Petersplatz 1, 4001 Basel, Switzerland
5
Faculty of Pharmacy, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000 Porto Alegre RS, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Muhammad Ilias and Charles L. Cantrell
Received: 9 April 2018 / Revised: 23 May 2018 / Accepted: 24 May 2018 / Published: 26 May 2018
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Abstract

Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential. View Full-Text
Keywords: Crinum amabile; augustine N-oxide; buphanisine N-oxide; biological activities Crinum amabile; augustine N-oxide; buphanisine N-oxide; biological activities
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Tallini, L.R.; Torras-Claveria, L.; Borges, W.S.; Kaiser, M.; Viladomat, F.; Zuanazzi, J.A.S.; Bastida, J. N-oxide alkaloids from Crinum amabile (Amaryllidaceae). Molecules 2018, 23, 1277.

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