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Molecules 2018, 23(6), 1279; https://doi.org/10.3390/molecules23061279

Four New Lignans from Kadsura Interior and Their Bioactivity

1
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
2
Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China
*
Author to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 30 April 2018 / Revised: 24 May 2018 / Accepted: 25 May 2018 / Published: 26 May 2018
(This article belongs to the Collection Bioactive Compounds)
Full-Text   |   PDF [936 KB, uploaded 26 May 2018]   |  

Abstract

A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new lignans, named kadsutherin E–H (14), together with two known lignans (56). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 16 exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F (2) showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%. View Full-Text
Keywords: Kadsura interior; lignan; kadsutherin E-H; anti-platelet aggregation Kadsura interior; lignan; kadsutherin E-H; anti-platelet aggregation
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Liu, J.-S.; Zhang, J.; Qi, Y.-D.; Jia, X.-G.; Zhang, B.-G.; Liu, H.-T. Four New Lignans from Kadsura Interior and Their Bioactivity. Molecules 2018, 23, 1279.

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