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Molecules 2018, 23(5), 1181; https://doi.org/10.3390/molecules23051181

Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana

1,†
,
2,†
,
1
,
1
,
1
and
1,*
1
The Key Laboratory of Miao Medicine of Guizhou Province, Guiyang College of Traditional Chinese Medicine, Guiyang 550025, Guizhou, China
2
The Ethnical Medicine Research Institute of Qian Dong Nan Miao and Dong Autonomous Prefecture, Kaili 556000, Guizhou, China
These authors contributed equally to this work and are co-first authors.
*
Author to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 10 May 2018 / Accepted: 10 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue Advances in Plant Alkaloid Research)
View Full-Text   |   Download PDF [575 KB, uploaded 15 May 2018]   |  

Abstract

Three new steroidal alkaloids with an unusual 3α tigloylamide group, named sarchookloides A–C (13), were isolated along with four known compounds (47) from the roots of Sarcococca hookeriana. Their structures and relative configuration were elucidated on the basis of spectroscopic methods including MS, UV, IR, 1D, and 2D NMR data. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines: Hela, A549, MCF-7, SW480, and CEM in vitro. All three amide substituted steroidal alkaloids exhibited significant cytotoxic activities with IC50 values of 1.05–31.83 μM. View Full-Text
Keywords: Sarcococca hookeriana; sarchookloides A–C; steroidal alkaloid; cytotoxicity Sarcococca hookeriana; sarchookloides A–C; steroidal alkaloid; cytotoxicity
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He, K.; Wang, J.; Zou, J.; Wu, J.; Huo, S.; Du, J. Three New Cytotoxic Steroidal Alkaloids from Sarcococca hookeriana. Molecules 2018, 23, 1181.

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