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Molecules 2018, 23(4), 934; https://doi.org/10.3390/molecules23040934

Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi

1
Instituto de Química, Universidad de Antioquia, Medellín 050010, Colombia
2
Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia
3
Jardín Botánico Joaquín Antonio Uribe, Medellín 050010, Colombia
*
Author to whom correspondence should be addressed.
Received: 6 February 2018 / Revised: 7 March 2018 / Accepted: 14 March 2018 / Published: 17 April 2018
(This article belongs to the Special Issue Advances in Plant Alkaloid Research)
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Abstract

A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied. View Full-Text
Keywords: canthin-6-one; Picrolemma huberi; Simaroubaceae; antiplasmodial activity canthin-6-one; Picrolemma huberi; Simaroubaceae; antiplasmodial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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López, C.; Pastrana, M.; Ríos, A.; Cogollo, A.; Pabón, A. Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi. Molecules 2018, 23, 934.

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