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Molecules 2018, 23(5), 1169; https://doi.org/10.3390/molecules23051169

Hydroxypropyl-β-cyclodextrin for Delivery of Baicalin via Inclusion Complexation by Supercritical Fluid Encapsulation

School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China
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Academic Editor: Bernard Martel
Received: 27 April 2018 / Revised: 11 May 2018 / Accepted: 11 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Cyclodextrin Chemistry 2018)
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Abstract

Over the years, various methods have been developed to enhance the solubility of insoluble drugs; however, most of these methods are time-consuming and labor intensive or involve the use of toxic materials. A method that can safely and effectively enhance the solubility of insoluble drugs is lacking. This study adopted baicalin as an insoluble drug model, and used hydroxypropyl-β-cyclodextrin for the delivery of baicalin via the inclusion complexation by supercritical fluid encapsulation. Different parameters for the complex preparation as well as the physicochemical properties of the complex have been investigated. Our results showed that when compared to the conventional solution mixing approach, supercritical fluid encapsulation enables a more precise control of the properties of the complex, and gives higher loading and encapsulation efficiency. It is anticipated that our reported method can be useful in enhancing the preparation efficiency of inclusion complexes, and can expand the application potential of insoluble herbal ingredients in treatment development and pharmaceutical formulation. View Full-Text
Keywords: baicalin; hydroxypropyl-β-cyclodextrin; supercritical fluid; inclusion complexation baicalin; hydroxypropyl-β-cyclodextrin; supercritical fluid; inclusion complexation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Li, Y.; He, Z.-D.; Zheng, Q.-E.; Hu, C.; Lai, W.-F. Hydroxypropyl-β-cyclodextrin for Delivery of Baicalin via Inclusion Complexation by Supercritical Fluid Encapsulation. Molecules 2018, 23, 1169.

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