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Molecules 2018, 23(5), 1150; https://doi.org/10.3390/molecules23051150

The Effect of Different Levels of Cu, Zn and Mn Nanoparticles in Hen Turkey Diet on the Activity of Aminopeptidases

1
Institute of Genetics and Animal Breeding, Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
2
Department of Animal Nutrition and Feed Management, Poznań University of Life Sciences, 60-637 Poznań, Poland
3
Department of Family Studies, Cardinal Stefan Wyszynski University in Warsaw, 01-815 Warszawa, Poland
4
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
*
Authors to whom correspondence should be addressed.
Received: 14 March 2018 / Revised: 24 April 2018 / Accepted: 9 May 2018 / Published: 11 May 2018
(This article belongs to the Section Nanochemistry)
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Abstract

The aim of the study was to estimate the influence of the different levels of Cu, Zn, and Mn nanoparticles on the activity of aminopeptidases in turkey. An experiment was carried out on 144 turkey hen Hybrid Converter. The birds were divided into groups given standard- and nanoparticle-supplementation of different level of copper (Cu 20, 10, 2 mg/kg), zinc (Zn 100, 50, 10 ppm), and manganese (Mn 100, 50, 10 ppm), covering respectively 100%, 50%, and 10% of the physiological demands for those minerals in the diet. The activity of aminopeptidases (alanyl: AlaAP, leucyl: LeuAP and arginyl: ArgAP) after supplementation of minerals was determined in the breast and thigh turkey muscle. The strongest effect of interaction among minerals supplementation form and dose on the activity levels of the aminopeptidases in thigh muscle was observed for nano-Cu already at the lowest dose of 2 mg/kg. In this dose (covering 10% of the birds’ demand) nano form of supplementation significantly increased the activity of Ala-, Leu-, and ArgAP (877, 201, and 719, respectively), compared to standard form of supplementation (461, 90.5, and 576, respectively). In turn, in breast muscle, after supplementation covering 10% of the demand with the nano-Cu, nano-Zn, and nano-Mn compared to the standard form, we did not observe any significant difference in the activity levels of any of the investigated aminopeptidases, except for AlaAP under Zn supplementation. Supplementation with the 20 mg/kg of Nano-Cu (100% of demand) and with 10 mg/kg of Nano-Cu (50% of demand) inhibited the activity of all of the three aminopeptidases in thigh muscle. Supplementation of the minerals in nano form into the diet, especially of Cu and Zn in the dose covering 10% of the demand is relevant to maintain homeostasis in turkey muscles, as indicated by the activity of the aminopeptidases. View Full-Text
Keywords: nanoparticles; turkey; aminopeptidases; poultry meat; nutrition; supplementation; lysosomal enzymes nanoparticles; turkey; aminopeptidases; poultry meat; nutrition; supplementation; lysosomal enzymes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jóźwik, A.; Marchewka, J.; Strzałkowska, N.; Horbańczuk, J.O.; Szumacher-Strabel, M.; Cieślak, A.; Lipińska-Palka, P.; Józefiak, D.; Kamińska, A.; Atanasov, A.G. The Effect of Different Levels of Cu, Zn and Mn Nanoparticles in Hen Turkey Diet on the Activity of Aminopeptidases. Molecules 2018, 23, 1150.

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