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Molecules 2018, 23(5), 1149; https://doi.org/10.3390/molecules23051149

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

1
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China
2
Department of Bioengineering, Wuhan Polytechnic, Wuhan 430074, China
*
Author to whom correspondence should be addressed.
Received: 2 April 2018 / Revised: 2 May 2018 / Accepted: 3 May 2018 / Published: 11 May 2018
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives (13), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods. They were identified as (1) 23-hydroxy-3,19-dioxo-olean-12-en-28-oic-acid; (2) 23-hydroxy-3,11-dioxo-olean-12-en-28-oic acid; and (3) 16α,23-dihydroxy-3-oxo-olean-12-en-28-oic acid. Compounds (110) inhibited the LPS-activated NO production in RAW264.7 cells. Furthermore, the anti-inflammatory characteristics of these compounds were confirmed on the basis of decreases in iNOS and NF-κB protein expression in RAW264.7 cells. View Full-Text
Keywords: Caulophyllum robustum; triterpene derivatives; anti-inflammatory Caulophyllum robustum; triterpene derivatives; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Qin, B.-H.; Liu, X.-Q.; Yuan, Q.-Y.; Wang, J.; Han, H.-Y. Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells. Molecules 2018, 23, 1149.

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