Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet
AbstractWe have studied a preventive effect of polyphenol-rich bee pollen ethanol extract (EEP) against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL6 mice. Supplementing the diet with EEP in the doses of 0.1 g/kg body mass (BM) and 1 g/kg BM resulted in a decrease of total cholesterol by 31% and 35%, respectively. It also decreased the level of low density lipoproteins by 67% and 90%, respectively. No differences in the levels of high density lipoprotein and triacylglycerols were observed. EEP reduced the level of ox-LDL by 33% and 47%, ADMA by 13% and 51%, ACE by 17% and 30%, as well as ANG II by 11% and 15% in a dose-dependent manner, which proves a protective effect of EEP in a high-fat diet. EEP reduces and/or prevents hepatic steatosis and degenerative changes caused by a high-fat diet in C57BL6 mice, which indicates its hepatoprotective effect. EEP used with standard feed does not disturb a normal concentration of the assayed parameters. View Full-Text
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Rzepecka-Stojko, A.; Kabała-Dzik, A.; Kubina, R.; Jasik, K.; Kajor, M.; Wrześniok, D.; Stojko, J. Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet. Molecules 2018, 23, 805.
Rzepecka-Stojko A, Kabała-Dzik A, Kubina R, Jasik K, Kajor M, Wrześniok D, Stojko J. Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet. Molecules. 2018; 23(4):805.Chicago/Turabian Style
Rzepecka-Stojko, Anna; Kabała-Dzik, Agata; Kubina, Robert; Jasik, Krzysztof; Kajor, Maciej; Wrześniok, Dorota; Stojko, Jerzy. 2018. "Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet." Molecules 23, no. 4: 805.
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