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Molecules 2018, 23(4), 806; https://doi.org/10.3390/molecules23040806

β-Glucans: Multi-Functional Modulator of Wound Healing

1
Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska Cesta 21, 845 51 Bratislava, Slovakia
2
Department of Paediatrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Kollarova 2, 036 59 Martin, Slovakia
*
Author to whom correspondence should be addressed.
Academic Editor: Quan-Bin Han
Received: 20 March 2018 / Revised: 29 March 2018 / Accepted: 30 March 2018 / Published: 1 April 2018
(This article belongs to the Special Issue Advances in Natural Polysaccharides Research)
Full-Text   |   PDF [3161 KB, uploaded 3 May 2018]   |  

Abstract

β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases. View Full-Text
Keywords: polysaccharide; natural product; immunomodulator; wound repair polysaccharide; natural product; immunomodulator; wound repair
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Majtan, J.; Jesenak, M. β-Glucans: Multi-Functional Modulator of Wound Healing. Molecules 2018, 23, 806.

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