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Molecules 2018, 23(3), 546; https://doi.org/10.3390/molecules23030546

An Injectable, Dual Responsive, and Self-Healing Hydrogel Based on Oxidized Sodium Alginate and Hydrazide-Modified Poly(ethyleneglycol)

1
CAS Key Laboratory of Soft Matter Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China
2
Oil Production Technology Institute, Daqing Oilfield Company Ltd., Daqing 163453, China
*
Author to whom correspondence should be addressed.
Received: 6 February 2018 / Revised: 21 February 2018 / Accepted: 28 February 2018 / Published: 1 March 2018
(This article belongs to the Special Issue Stimuli-Responsive Polymeric Materials)
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Abstract

Oxidized sodium alginate is a handily modifiable polysaccharide owing to the pendant aldehyde groups which can form dynamic covalent bonds with amines, acylhydrazines, etc., providing oxidized sodium alginate-based hydrogels with stimuli-responsive properties. However, due to the stiffness and, in particular, the hydrophobicity of sodium alginate dialdehyde at low pH, the mechanical performance and pH stimuli responsiveness of oxidized sodium alginate-based hydrogels are still strictly limited. Herein, we report a new strategy to build an injectable, dual responsive, and self-healing hydrogel based on oxidized sodium alginate and hydrazide-modified poly(ethyleneglycol) (PEG). The hydrazide-modified PEG, referred to as PEG-DTP, acts as a macromolecule crosslinker. We found that the presence of PEG-DTP reduces the hydrophobicity of oxidized sodium alginate at low pH so effectively that even a pH-induced reversible sol-gel transitions can be realized. Meanwhile, the disulfide bonds in PEG-DTP endows the hydrogel with the other reversible sol-gel transitions by redox stimuli. In particular, due to the softness of PEG-DTP chains, mechanical performance was also enhanced significantly. Our results indicate we can easily integrate multi-stimuli responsiveness, injectability, and self-healing behavior together into an oxidized sodium alginate-based hydrogel merely by mixing an oxidized sodium alginate solution with PEG-DTP solution in certain proportions. View Full-Text
Keywords: oxidized sodium alginate; dynamic covalent bonds; stimuli-responsive; sol-gel transitions; injectable hydrogel; self-healing oxidized sodium alginate; dynamic covalent bonds; stimuli-responsive; sol-gel transitions; injectable hydrogel; self-healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wang, L.; Zhou, W.; Wang, Q.; Xu, C.; Tang, Q.; Yang, H. An Injectable, Dual Responsive, and Self-Healing Hydrogel Based on Oxidized Sodium Alginate and Hydrazide-Modified Poly(ethyleneglycol). Molecules 2018, 23, 546.

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