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Molecules 2018, 23(3), 512; https://doi.org/10.3390/molecules23030512

Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases

Tea Research Institute, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
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Received: 18 January 2018 / Revised: 23 February 2018 / Accepted: 23 February 2018 / Published: 25 February 2018
(This article belongs to the Collection Recent Advances in Flavors and Fragrances)
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Abstract

As the population ages, neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a heavy burden on society and families. The pathogeneses of PD and AD are complex. There are no radical cures for the diseases, and existing therapeutic agents for PD and AD have diverse side effects. Tea contains many bioactive components such as polyphenols, theanine, caffeine, and theaflavins. Some investigations of epidemiology have demonstrated that drinking tea can decrease the risk of PD and AD. Tea polyphenols can lower the morbidity of PD and AD by reducing oxidative stress and regulating signaling pathways and metal chelation. Theanine can inhibit the glutamate receptors and regulate the extracellular concentration of glutamine, presenting neuroprotective effects. Additionally, the neuroprotective mechanisms of caffeine and theaflavins may contribute to the ability to antagonize the adenosine receptor A2AR and the antioxidant properties, respectively. Thus, tea bioactive components might be useful for neuronal degeneration treatment in the future. In the present paper, the neuro protection and the mechanisms of tea and its bioactive components are reviewed. Moreover, the potential challenges and future work are also discussed. View Full-Text
Keywords: neuronal degeneration; Parkinson’s disease; Alzheimer’s disease; polyphenols; theanine; caffeine; theaflavins neuronal degeneration; Parkinson’s disease; Alzheimer’s disease; polyphenols; theanine; caffeine; theaflavins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chen, S.-Q.; Wang, Z.-S.; Ma, Y.-X.; Zhang, W.; Lu, J.-L.; Liang, Y.-R.; Zheng, X.-Q. Neuroprotective Effects and Mechanisms of Tea Bioactive Components in Neurodegenerative Diseases. Molecules 2018, 23, 512.

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