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Molecules 2018, 23(2), 296; https://doi.org/10.3390/molecules23020296

A Systematic Review of Antiamyloidogenic and Metal-Chelating Peptoids: Two Structural Motifs for the Treatment of Alzheimer’s Disease

Department of Chemistry, Muhlenberg College, 2400 Chew Street, Allentown, PA 18104, USA
Received: 10 January 2018 / Revised: 27 January 2018 / Accepted: 30 January 2018 / Published: 31 January 2018
(This article belongs to the Special Issue 25th Anniversary of the Amyloid Hypothesis and Alzheimer Disease)
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Abstract

Alzheimer’s disease (AD) is an incurable form of dementia affecting millions of people worldwide and costing billions of dollars in health care-related payments, making the discovery of a cure a top health, societal, and economic priority. Peptide-based drugs and immunotherapies targeting AD-associated beta-amyloid (Aβ) aggregation have been extensively explored; however, their therapeutic potential is limited by unfavorable pharmacokinetic (PK) properties. Peptoids (N-substituted glycine oligomers) are a promising class of peptidomimetics with highly tunable secondary structures and enhanced stabilities and membrane permeabilities. In this review, the biological activities, structures, and physicochemical properties for several amyloid-targeting peptoids will be described. In addition, metal-chelating peptoids with the potential to treat AD will be discussed since there are connections between the dysregulation of certain metals and the amyloid pathway. View Full-Text
Keywords: Alzheimer’s disease; peptoids; peptidomimetics; beta-amyloid aggregation; beta-amyloid aggregation inhibitors; pharmacokinetics; metal chelators Alzheimer’s disease; peptoids; peptidomimetics; beta-amyloid aggregation; beta-amyloid aggregation inhibitors; pharmacokinetics; metal chelators
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Young, S.C. A Systematic Review of Antiamyloidogenic and Metal-Chelating Peptoids: Two Structural Motifs for the Treatment of Alzheimer’s Disease. Molecules 2018, 23, 296.

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