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Molecules 2018, 23(1), 57; doi:10.3390/molecules23010057

Cytotoxic Terpenoids from the Roots of Dracocephalum taliense

College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China
Author to whom correspondence should be addressed.
Received: 5 November 2017 / Revised: 12 December 2017 / Accepted: 14 December 2017 / Published: 27 December 2017
(This article belongs to the Collection Herbal Medicine Research)
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A chemical investigation of methanol extract from the roots of Dracocephalum taliense led to the isolation of a new aromatic abietane diterpenoid, 12-methoxy-18-hydroxy-sugiol (1), and one highly-oxygenated ursane triterpenoid, 2α,3α-dihydroxy-11α,12α-epoxy-urs-28,13β-olide (2), together with 15 known natural products (317). Among these, compounds 113 and 1517 were detected for the first time in the genus of Dracocephalum. The structures of all of these isolates were determined by extensively spectroscopic analyses. In the anti-inflammatory assay, compounds 1 and 2 had no obvious inhibitory activity on the release of cytokine IL-2 in lipopolysaccharide-induced RAW 264.7 macrophages. However, compound 2 exhibited significant cytotoxic activity against cell lines HepG2 (IC50 = 6.58 ± 0.14 μM) and NCI-H1975 (IC50 = 7.17 ± 0.26 μM). View Full-Text
Keywords: Dracocephalum taliense; abietane diterpenoid; ursane triterpenoid; cytotoxicity; structural elucidation Dracocephalum taliense; abietane diterpenoid; ursane triterpenoid; cytotoxicity; structural elucidation

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Deng, Y.; Hua, J.; Wang, W.; Zhan, Z.; Wang, A.; Luo, S. Cytotoxic Terpenoids from the Roots of Dracocephalum taliense. Molecules 2018, 23, 57.

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