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Molecules 2018, 23(1), 33; doi:10.3390/molecules23010033

Recent Advances in Organocatalyzed Domino C–C Bond-Forming Reactions

Department of Chemistry and Biochemistry, Berry College, P.O. Box 495016, Mt. Berry, GA 30149, USA
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Received: 11 December 2017 / Revised: 19 December 2017 / Accepted: 22 December 2017 / Published: 23 December 2017
(This article belongs to the Collection Recent Advances in Organocatalysis)
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Abstract

Reactions that form a C–C bond make up a foundational pillar of synthetic organic chemistry. In addition, organocatalysis has emerged as an easy, environmentally-friendly way to promote this type of bond formation. Since around 2000, organocatalysts have been used in a variety of C–C bond-forming reactions including Michael and aldol additions, Mannich-type reactions, and Diels–Alder reactions, to name a few. Many of these methodologies have been refined and further developed to include cascade and domino processes. This review will focus on recent advances in this area with an emphasis on methodologies having applications in the synthesis of biologically-significant compounds. View Full-Text
Keywords: organocatalysis; domino; tandem; Henry; aldol; Mannich organocatalysis; domino; tandem; Henry; aldol; Mannich
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Evans, C.S.; Davis, L.O. Recent Advances in Organocatalyzed Domino C–C Bond-Forming Reactions. Molecules 2018, 23, 33.

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