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Molecules 2018, 23(1), 157; doi:10.3390/molecules23010157

Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine

1
Department of Soil Sciences, University of Agronomical Sciences and Veterinary Medicine, 59 Mărăşti Str., Sector 1, 011464 Bucharest, Romania
2
Department of Microbiology, Faculty of Biology, University of Bucharest, 1–3 Aleea Portocalelor Str., 60101 Bucharest, Romania
3
Research Institute of the University of Bucharest–ICUB, Life, Environmental and Earth Sciences Division, Spl. Independentei 91–95, 010271 Bucharest, Romania
4
Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave., 030304 Bucharest, Romania
5
SC Sanimed International Impex SRL, Sos Bucuresti Magurele, nr. 70F, Sector 5, 051434 Bucharest, Romania
6
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany
7
Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90–92 Panduri Str., 050663 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Received: 29 November 2017 / Revised: 5 January 2018 / Accepted: 7 January 2018 / Published: 12 January 2018
(This article belongs to the Section Inorganic Chemistry)
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Abstract

The synthesis, structural characterization, cytotoxicity, and antimicrobial properties of four new complexes formed by employing acrylate anion and 2,2′-bipyridine are reported herein. X-ray crystallography revealed the trinuclear nature of [Mn3(2,2′-bipy)2(C3H3O2)6] (1), meanwhile complexes with general formula [M(2,2′-bipy)(C3H3O2)2(H2O)x]∙yH2O ((2) M: Ni, x = 1, y = 0; (3) M: Cu, x = 1, y = 0; (4) M: Zn, x = 0, y = 1; 2,2′-bipy: 2,2′-bipyridine; C3H3O2: acrylate anion) were shown to be mononuclear. The lowest minimum inhibitory concentration (MIC) of 128 μg mL−1 was recorded for all four tested complexes against Candida albicans, for complex (3) against Escherichia coli, and for complex (4) against Staphylocococcus aureus. Compounds (3) and (4) were also potent efflux pumps activity inhibitors (EPI), proving their potential for use in synergistic combinations with antibiotics. Complexes (1)–(4) revealed that they were not cytotoxic to HCT-8 cells. They also proved to interfere with the cellular cycle of tumour HCT-8 cells by increasing the number of cells found in the S and G2/M phases. Taken together, these results demonstrate the potential of zinc and copper complexes for use in the development of novel antimicrobial and anti-proliferative agents. View Full-Text
Keywords: 2,2′-bipyridine complexes; acrylato ligand; trinuclear complex; antifungal activity 2,2′-bipyridine complexes; acrylato ligand; trinuclear complex; antifungal activity
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Vasile Scăețeanu, G.; Chifiriuc, M.C.; Bleotu, C.; Kamerzan, C.; Măruţescu, L.; Daniliuc, C.G.; Maxim, C.; Calu, L.; Olar, R.; Badea, M. Synthesis, Structural Characterization, Antimicrobial Activity, and In Vitro Biocompatibility of New Unsaturated Carboxylate Complexes with 2,2′-Bipyridine. Molecules 2018, 23, 157.

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