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Molecules 2017, 22(9), 1543; doi:10.3390/molecules22091543

An NMR-Based Metabolomic Approach to Unravel the Preventive Effect of Water-Soluble Extract from Dendrobium officinale Kimura & Migo on Streptozotocin-Induced Diabetes in Mice

1
Institute of Metabonomics & Medical NMR, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China
2
Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China
3
Department of Neurology Rehabilitation, Wenzhou Chinese Medicine Hospital, Wenzhou 325000, China
*
Author to whom correspondence should be addressed.
Received: 24 August 2017 / Accepted: 11 September 2017 / Published: 15 September 2017
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Abstract

Dendrobium officinale Kimura & Migo (D. officinale) is a precious herbal medicine. In this study, we investigated metabolic mechanism underlying the effect of D. officinale water extract (DOWE) on diabetes prevention in mice after streptozotocin (STZ) exposure using NMR-based metabolomics. Interestingly, we found a decrease in blood glucose and an increase in liver glycogen in mice pretreated with DOWE after STZ exposure. The DOWE pretreatment significantly increased citrate and glutamine in the serum as well as creatine, alanine, leucine, isoleucine, valine, glutamine, glutathione and taurine in the liver of STZ-treated mice. Furthermore, serum glucose was significantly negatively correlated with citrate, pyruvate, alanine, isoleucine, histidine and glutamine in the serum as well as alanine and taurine in the liver. These findings suggest that the effect of DOWE on diabetes prevention may be linked to increases in liver glycogen and taurine as well as the up-regulation of energy and amino acid metabolism. View Full-Text
Keywords: amino acid; diabetes; energy metabolism; glucose-lowering; liver amino acid; diabetes; energy metabolism; glucose-lowering; liver
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Zheng, H.; Pan, L.; Xu, P.; Zhu, J.; Wang, R.; Zhu, W.; Hu, Y.; Gao, H. An NMR-Based Metabolomic Approach to Unravel the Preventive Effect of Water-Soluble Extract from Dendrobium officinale Kimura & Migo on Streptozotocin-Induced Diabetes in Mice. Molecules 2017, 22, 1543.

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