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Molecules 2017, 22(9), 1537; doi:10.3390/molecules22091537

Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit

1
Department of General Surgery, Medical School, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
2
Department of Biochemistry, Medical School, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
3
Department of Anesthesiology and Reanimation, Medical School, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
4
Department of Biostatistics, Medical School, Eskisehir Osmangazi University, Eskisehir 26480, Turkey
*
Author to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 10 September 2017 / Accepted: 10 September 2017 / Published: 12 September 2017
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Abstract

Disruption of nocturnal sleep in an intensive care unit may remarkably affect production of melatonin, which is also known to have anti-inflammatory properties. In the present study, we aimed to investigate the effect of sleep quality on melatonin levels and inflammation after surgery. Thus, we compared the patients, who were screened in the side-rooms where the lights were dimmed and noise levels were reduced, with the patients who received usual care. Preoperative and postoperative urine 6-sulphatoxymelatonin, serum interleukin-1 (IL-1), interleukin-6 (IL-6), and c-reactive protein (CRP) levels were measured and data on sleep quality was collected using the Richards–Campbell Sleep Questionnaire. Postoperative CRP and IL-6 levels were greater in the control group than in the experimental group, whereas postoperative 24 h melatonin levels were greater than preoperative levels and the difference was steeper in the experimental group in concordance with sleep quality scores. Thus, the regulation of light and noise in ICUs may help the recovery after major surgeries in patients, potentially by increasing melatonin production, which has anti-inflammatory properties. View Full-Text
Keywords: melatonin; intensive care unit; sleep quality; surgery; inflammatory response melatonin; intensive care unit; sleep quality; surgery; inflammatory response
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MDPI and ACS Style

Yaşar, N.F.; Badak, B.; Canik, A.; Baş, S.Ş.; Uslu, S.; Öner, S.; Ateş, E. Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit. Molecules 2017, 22, 1537.

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