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Molecules 2017, 22(9), 1535; doi:10.3390/molecules22091535

The Anti-Proliferation Activity and Mechanism of Action of K12[V18O42(H2O)]∙6H2O on Breast Cancer Cell Lines

School of Public Health, Jilin University, Changchun 130021, Jilin, China
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Received: 11 July 2017 / Revised: 6 September 2017 / Accepted: 7 September 2017 / Published: 12 September 2017
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
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Abstract

Polyoxometalates (POMs) are inorganic clusters that possess potential anti-bacterial, anti-viral, and anti-tumor activities. Herein, the in vitro anti-proliferation activities of K12[V18O42(H2O)]∙6H2O (V18) have been investigated on the MCF-7 and MDA-MB-231 cell lines. The results indicated that V18 could inhibit the proliferation of MCF-7 (IC50, 11.95 μM at 48 h) in a dose-dependent manner compared to the positive control, 5-fluorouracil (5-Fu, p < 0.05). The anti-proliferation activity of V18 might be mediated by arrest of the MCF-7 cells in the G2/M phase and induction of apoptosis and necrosis. Moreover, V18 can effectively quench the fluorescence of ctDNA. The binding mode between them may be groove or outside stacking binding. V18 can also effectively quench the intrinsic fluorescence of bovine serum albumin (BSA) and human serum albumin (HSA) via static quenching, and changed the conformation of BSA and HSA. View Full-Text
Keywords: polyoxometalates; anti-proliferation; DNA binding effect; BSA binding effect polyoxometalates; anti-proliferation; DNA binding effect; BSA binding effect
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MDPI and ACS Style

Qi, W.; Zhang, B.; Qi, Y.; Guo, S.; Tian, R.; Sun, J.; Zhao, M. The Anti-Proliferation Activity and Mechanism of Action of K12[V18O42(H2O)]∙6H2O on Breast Cancer Cell Lines. Molecules 2017, 22, 1535.

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