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Molecules 2017, 22(9), 1503; doi:10.3390/molecules22091503

FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation

Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, Chengdu University, 168 Hua Guan Road, Chengdu 610052, China
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Received: 22 August 2017 / Revised: 7 September 2017 / Accepted: 7 September 2017 / Published: 11 September 2017
(This article belongs to the Special Issue Catalytic Cascade Reactions)
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Abstract

An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones. View Full-Text
Keywords: FeCl3∙6H2O; TMSBr; dihydropyrimidinones; dihydropyrimidinethiones; microwave irradiation FeCl3∙6H2O; TMSBr; dihydropyrimidinones; dihydropyrimidinethiones; microwave irradiation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, F.; Jia, X.; Li, P.; Zhao, J.; Huang, J.; Li, H.; Li, L. FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation. Molecules 2017, 22, 1503.

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