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Special Issue "Catalytic Cascade Reactions"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (10 October 2017)

Special Issue Editor

Guest Editor
Prof. Dr. Helena C. Malinakova

Department of Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA
Website | E-Mail
Interests: organometallics; palladacycles; heterocycles; palladium-catalyzed reactions; multi-component reactions; sequential metal-catalyzed reactions; pot economy

Special Issue Information

Dear Colleagues,

In recent years, the drive to maximize the brevity of synthetic schemes came to the forefront of organic synthesis. The emergence of various cascade reactions, also referrred to as domino or tandem reactions, brought about major breakthroughs in this field. Cascade reactions create multiple carbon–carbon bonds in a single synthetic operation and rapidly achieve a significant increase in the molecular complexity. Cascade reactions that are performed under catalytic conditions are the most desirable from the standpoint of overall atom economy.

Strategic applications of cascade reactions with diverse mechanistic foundations (reactions with ionic, radical or metal-containing intermediates) in total synthesis delivered impressively short and efficient routes to highly complex organic structures.

The aims of this Special Issue is to highlight recent advances in the design, development and applications of catalytic cascade reactions to organic synthesis. Of special interest are catalytic asymmetric reactions, as well as protocols that could trigger stereo-divergent or regio-divergent pathways by a change in the features of the catalytic system.

Prof. Dr. Helena C. Malinakova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Step economy
  • Carbon economy
  • Cascade reactions
  • Tandem reactions
  • Domino reactions
  • Asymmetric catalysis
  • Transition metal-catalysis
  • Organocatalysis
  • Single-electron transfer
  • Photocatalysis
  • Stereo-divergent
  • Regio-divergent

Published Papers (2 papers)

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Research

Open AccessArticle An Efficient, Eco-friendly and Sustainable One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Directly from Alcohols Catalyzed by Heteropolyanion-Based Ionic Liquids
Molecules 2017, 22(9), 1531; doi:10.3390/molecules22091531
Received: 22 August 2017 / Accepted: 7 September 2017 / Published: 11 September 2017
PDF Full-text (1216 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Efficient, eco-friendly and sustainable access to 3,4-dihydropyrimidin-2(1H)-ones directly from alcohols under microwave and solvent-free conditions has been reported. The practical protocol involves heteropolyanion-based catalyzed oxidation of alcohols to aldehydes with NaNO3 as the oxidant followed by cyclocondensation with dicarbonyl compounds
[...] Read more.
Efficient, eco-friendly and sustainable access to 3,4-dihydropyrimidin-2(1H)-ones directly from alcohols under microwave and solvent-free conditions has been reported. The practical protocol involves heteropolyanion-based catalyzed oxidation of alcohols to aldehydes with NaNO3 as the oxidant followed by cyclocondensation with dicarbonyl compounds and urea or thiourea in a two-step, one-pot manner. Compatibility with different functional groups, good to excellent yields and reusable catalysts are the main highlights. The utilization of alcohols instead of aldehydes is a valid and green alternative to the classical Biginelli reaction. Full article
(This article belongs to the Special Issue Catalytic Cascade Reactions)
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Open AccessArticle FeCl3∙6H2O/TMSBr-Catalyzed Rapid Synthesis of Dihydropyrimidinones and Dihydropyrimidinethiones under Microwave Irradiation
Molecules 2017, 22(9), 1503; doi:10.3390/molecules22091503
Received: 22 August 2017 / Revised: 7 September 2017 / Accepted: 7 September 2017 / Published: 11 September 2017
PDF Full-text (13947 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up,
[...] Read more.
An efficient and practical protocol has been developed to synthesize dihydropyrimidinones and dihydropyrimidinethiones through FeCl3∙6H2O/TMSBr-catalyzed three-component cyclocondensation under microwave irradiation. This approach features high yields, broad substrate scope, short reaction time, mild reaction conditions, operational simplicity and easy work-up, thus affording a versatile method for the synthesis of dihydropyrimidinones and dihydropyrimidinethiones. Full article
(This article belongs to the Special Issue Catalytic Cascade Reactions)
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