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Molecules 2017, 22(9), 1454; doi:10.3390/molecules22091454

Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release

1
Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan
2
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
3
Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
4
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
5
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
6
Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan
*
Author to whom correspondence should be addressed.
Received: 3 August 2017 / Revised: 30 August 2017 / Accepted: 30 August 2017 / Published: 1 September 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [719 KB, uploaded 1 September 2017]   |  

Abstract

Investigation of the chemical constituents from the fruits of Citrus medica L. var. sarcodactylis Swingle has led to the characterization of a new sesquiterpene 1 along with thirty-two known compounds. The structure of 1 was established on the basis of 2D NMR spectroscopic and mass spectrometric analyses, and the known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. In addition, most of the isolated compounds were evaluated for the activity assayed by the in vitro inhibition of superoxide anion generation and elastase release by human neutrophils. The results showed that only 6,7-dimethoxycoumarin (5) exhibited significant inhibition of superoxide anion generation, with IC50 value of 3.8 ± 1.4 μM. View Full-Text
Keywords: Citrus medica L. var. sarcodactylis Swingle; Rutaceae; sesquiterpene; citrumedin-C; superoxide anion formation; elastase release Citrus medica L. var. sarcodactylis Swingle; Rutaceae; sesquiterpene; citrumedin-C; superoxide anion formation; elastase release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chan, Y.-Y.; Hwang, T.-L.; Kuo, P.-C.; Hung, H.-Y.; Wu, T.-S. Constituents of the Fruits of Citrus medica L. var. sarcodactylis and the Effect of 6,7-Dimethoxy-coumarin on Superoxide Anion Formation and Elastase Release. Molecules 2017, 22, 1454.

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