Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity
AbstractHaematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1); 3-deoxysappanchalcone (2); three homoisoflavonoids known as hematoxylol A (3); 4-O-methylhematoxylol (4); and, hematoxin (5). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23) fractions HcF7 (EC50 = 61.75 ± 3.55) and HcF9 (EC50 = 125.5 ± 10.65) and compounds 1 (EC50 = 16.06 ± 2.15) and 2 (EC50 = 25.37 ± 3.47) of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0) as a positive control. View Full-Text
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Escobar-Ramos, A.; Lobato-García, C.E.; Zamilpa, A.; Gómez-Rivera, A.; Tortoriello, J.; González-Cortazar, M. Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity. Molecules 2017, 22, 1405.
Escobar-Ramos A, Lobato-García CE, Zamilpa A, Gómez-Rivera A, Tortoriello J, González-Cortazar M. Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity. Molecules. 2017; 22(9):1405.Chicago/Turabian Style
Escobar-Ramos, Armando; Lobato-García, Carlos E.; Zamilpa, Alejandro; Gómez-Rivera, Abraham; Tortoriello, Jaime; González-Cortazar, Manasés. 2017. "Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity." Molecules 22, no. 9: 1405.
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