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Molecules 2017, 22(9), 1405; doi:10.3390/molecules22091405

Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity

1
Academics Division of Basic Sciences, University Juárez Autonomous of Tabasco, Highway Cunduacán-Jalpa Km. 0.5, Cunduacán Tabasco 86690, Mexico
2
Southern Biomedical Research, Mexican Institute of Social Security, Argentina No. 1, Col. Centro, 62790 Xochitepec, Mexico
*
Authors to whom correspondence should be addressed.
Received: 13 July 2017 / Revised: 18 August 2017 / Accepted: 18 August 2017 / Published: 24 August 2017
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Haematoxylum campechianum is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (1); 3-deoxysappanchalcone (2); three homoisoflavonoids known as hematoxylol A (3); 4-O-methylhematoxylol (4); and, hematoxin (5). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC50 = 62.11 ± 3.23) fractions HcF7 (EC50 = 61.75 ± 3.55) and HcF9 (EC50 = 125.5 ± 10.65) and compounds 1 (EC50 = 16.06 ± 2.15) and 2 (EC50 = 25.37 ± 3.47) of Haematoxylum campechianum present significant relaxing activity as compared to papaverine (EC50 = 20.08 ± 2.0) as a positive control. View Full-Text
Keywords: homoisoflavonoids; Haematoxylum campechianum; chalcone; spasmolytic homoisoflavonoids; Haematoxylum campechianum; chalcone; spasmolytic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Escobar-Ramos, A.; Lobato-García, C.E.; Zamilpa, A.; Gómez-Rivera, A.; Tortoriello, J.; González-Cortazar, M. Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity. Molecules 2017, 22, 1405.

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