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Molecules 2017, 22(8), 1336; doi:10.3390/molecules22081336

Human Adenocarcinoma Cell Line Sensitivity to Essential Oil Phytocomplexes from Pistacia Species: a Multivariate Approach

1
Maria Paola Belloni Center for Personalized Medicine, Data Medica Group (Synlab Limited), 35100 Padova, Italy
2
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35100 Padova, Italy
3
Department of Biomedical Sciences, University of Padova, 35100 Padova, Italy
This work is dedicated to the memory of Maria Paola Belloni Regazzo, who, back in 1999 had the idea of looking into biological activities of Pistacia with the aim of identifying new antitumoral strategies and has sustained and guided the team of scientists to the results presented here.
*
Author to whom correspondence should be addressed.
Received: 12 July 2017 / Revised: 8 August 2017 / Accepted: 8 August 2017 / Published: 11 August 2017
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [2821 KB, uploaded 17 August 2017]   |  

Abstract

Principal component analysis (PCA) multivariate analysis was applied to study the cytotoxic activity of essential oils from various species of the Pistacia genus on human tumor cell lines. In particular, the cytotoxic activity of essential oils obtained from P. lentiscus, P. lentiscus var. chia (mastic gum), P. terebinthus, P. vera, and P. integerrima, was screened on three human adenocarcinoma cell lines: MCF-7 (breast), 2008 (ovarian), and LoVo (colon). The results indicate that all the Pistacia phytocomplexes, with the exception of mastic gum oil, induce cytotoxic effects on one or more of the three cell lines. PCA highlighted the presence of different cooperating clusters of bioactive molecules. Cluster variability among species, and even within the same species, could explain some of the differences seen among samples suggesting the presence of both common and species-specific mechanisms. Single molecules from one of the most significant clusters were tested, but only bornyl-acetate presented cytotoxic activity, although at much higher concentrations (IC50 = 138.5 µg/mL) than those present in the essential oils, indicating that understanding of the full biological effect requires a holistic vision of the phytocomplexes with all its constituents. View Full-Text
Keywords: Pistacia; terpenes; cytotoxic; principal component analysis Pistacia; terpenes; cytotoxic; principal component analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Buriani, A.; Fortinguerra, S.; Sorrenti, V.; Dall’Acqua, S.; Innocenti, G.; Montopoli, M.; Gabbia, D.; Carrara, M. Human Adenocarcinoma Cell Line Sensitivity to Essential Oil Phytocomplexes from Pistacia Species: a Multivariate Approach. Molecules 2017, 22, 1336.

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