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Molecules 2017, 22(8), 1280; doi:10.3390/molecules22081280

Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China

1
School of Pharmaceutical Sciences, Jilin University, Fujin Road 1266, Changchun 130021, China
2
National and Local Joint Engineering Research Center for Ginseng Innovative Drugs Development, Western Chaoyang Road 45, Changchun 130021, China
*
Authors to whom correspondence should be addressed.
Received: 5 July 2017 / Revised: 25 July 2017 / Accepted: 29 July 2017 / Published: 3 August 2017
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [1608 KB, uploaded 3 August 2017]   |  

Abstract

Platycodonis radix is extensively used for treating cough, excessive phlegm, sore throat, bronchitis and asthma in the clinic. Meanwhile, the stems, leaves and seeds of Platycodon grandiflorum (PG) have some pharmaceutical activities such as anti-inflammation and anti-oxidation effects, etc. These effects must be caused by the different metabolites in various parts of herb. In order to profile the different parts of PG, the ultra-high performance liquid chromatography combined with quadrupole time-of- flight mass spectrometry (UPLC-QTOF-MSE) coupled with UNIFI platform and multivariate statistical analyses was used in this study. Consequently, for the constituent screening, 73, 42, 35, 44 compounds were characterized from the root, stem, leaf and seed, respectively. The stem, leaf and seed contain more flavonoids but few saponins that can be easily discriminated in the root. For the metabolomic analysis, 15, 5, 7, 11 robust biomarkers enabling the differentiation among root, stem, leaf and seed, were discovered. These biomarkers can be used for rapid identification of four different parts of PG grown in northeast China. View Full-Text
Keywords: Platycodon grandiflorum; nontargeted metabolomic analysis; different part; UPLC-QTOF-MSE Platycodon grandiflorum; nontargeted metabolomic analysis; different part; UPLC-QTOF-MSE
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, C.; Zhang, N.; Wang, Z.; Qi, Z.; Zhu, H.; Zheng, B.; Li, P.; Liu, J. Nontargeted Metabolomic Analysis of Four Different Parts of Platycodon grandiflorum Grown in Northeast China. Molecules 2017, 22, 1280.

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